Event Type: Warning
Event Source: EventSystem
Event Category: Firing Agent
Event ID: 4100

Description:
The COM+ Event System failed to create an instance of the subscriber {C2F23AE4-82D8-456F-A4AF-A2655D8CA726}. CoCreateInstanceEx returned HRESULT 8000401A.

Side Note: The following error has also reported which is relevant:

The COM+ Event System failed to create an instance of the subscriber {C2F23AE4-82D8-456F-A4AF-A2655D8CA726}. StandardCreateInstance returned HRESULT 8000401A.

Contributed By: Chip
Remove client via ccmclean.exe, reinstall. This usually fixes it.  If the problem is widespread (check Event Log on numerous clients), or if reinstalling doesn't fix it, call PSS as there is a hotfix (831648 "Event ID 4100 or Event ID 4356 is logged in the application event log of Advanced Clients in Systems Management Server 2003").

The hotfix necessitates a change on the client end, which must be accomplished via a patch (.msp) since the client is now installed via .msi.  As a result, applying the hotfix to the site server does not proliferate the change to existing clients, nor does it apply it to newly installed clients.

Thus, one must create a standing Advertisement that will update all existing clients and new ones as they are installed (or exploit GPO or other means to execute). Rather a conspicuous "band-aid", I'm afraid.

I suspect that when SP1 is released, it will likely contain a recompiled update of the client installation .msi, and thus eliminate the need for the separate patch.

Contributed By: Mark A. Mears, MCSE [MSFT]
There is a hotfix that was created to address this issue. You can be sent this hotfix by contacting Microsoft Customer Service Product Support and requesting it. This will be a no-charge incident.
 

To see other SMS 2003 Troubleshooting FAQs click here.